Home Addiction Prescription Drugs Sleeping PillsUnderstanding Lunesta: Uses, Risks, and Treatments

Understanding Lunesta: Uses, Risks, and Treatments

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Lunesta, also known by its generic name eszopiclone, is a widely prescribed medication for managing insomnia, a condition characterized by difficulty initiating sleep, difficulty maintaining sleep, or frequent awakenings. This condition affects millions of individuals globally and it can significantly impact quality of life, causing fatigue, difficulty concentrating, and emotional distress. Lunesta offers relief by helping individuals fall asleep faster and maintain restful sleep. However, like all medications, it’s not without risks.

This article provides a comprehensive overview of Lunesta, covering its uses, side effects, addiction potential, and treatment options. By understanding the benefits and risks associated with Lunesta, patients and healthcare providers can make informed decisions about its use.

Lunesta, known by its generic name eszopiclone, is a prescription medication primarily used to treat insomnia. Classified as a non-benzodiazepine hypnotic ^[1], Lunesta belongs to a group of popular sleep-inducing sedatives referred to as “Z-drugs”. These drugs have become popular for their ability to address sleep-onset insomnia (trouble falling asleep) and sleep-maintenance insomnia (difficulty staying asleep), offering a comprehensive solution for individuals who struggle with restful sleep.

Insomnia is a major public health issue affecting between 6% to 10% ^[2] of adults in Western countries, and its impact extends beyond fatigue, contributing to reduced productivity, impaired memory, and an increased risk of mental health issues such as anxiety and depression. Eszopiclone is part of the new generation of hypnotics, designed to deliver the effectiveness of older benzodiazepines while addressing their well-known drawbacks. Compared to benzodiazepines, eszopiclone has a lower risk for abuse and dependence ^[2], making it a safer long-term option for managing insomnia.

How Lunesta works

Now that we’ve covered what Lunesta is used for, let’s dive deeper into how it works in your body to help manage insomnia. By understanding its mechanism of action, you’ll see how Lunesta promotes relaxation, helps you fall asleep faster, and supports staying asleep through the night.

Lunesta’s mechanism of action

The active ingredient in Lunesta is eszopiclone and although its precise mechanism of action ^[1]is unknown, it’s believed to boost a natural brain chemical called GABA. GABA’s main job is to calm down your brain and make it ready for rest. Lunesta boosts GABA’s effect by attaching to specific spots in the brain called GABA-A receptors, which slows down brain activity and helps you relax enough to sleep.

One of the best things about Lunesta is how quickly it works. Many people say they can fall asleep within 15 to 30 minutes of taking it. Plus, it lasts long enough – about six hours – to help if you wake up in the middle of the night. But because it stays in your system for a while, some people might feel a bit drowsy the next morning, especially if they take a higher dose.

How Lunesta works in your body

Once you take Lunesta, it follows a carefully designed process ^[1]in your body to help you get the sleep you need. Here’s what happens:

Starts working quickly: Lunesta begins to take effect within 30 minutes to 1 hour, depending on your metabolism. This fast action allows you to relax and drift off to sleep without a long waiting period. For best results, it’s recommended to take Lunesta right before bed, when you’re ready to sleep.
Lasts through the night: With a half-life of around six hours, Lunesta provides enough coverage to help you stay asleep throughout the night. This can be especially useful for people who wake up frequently during the night and struggle to fall back asleep. However, because of this extended duration, some people may feel mild drowsiness the next morning, especially if they take a higher dose or don’t get a full 7–8 hours of sleep.
Processed by the liver: After being absorbed into your bloodstream, Lunesta is broken down by the liver using specific enzymes (called CYP3A4 and CYP2E1). This is why individuals with liver problems may require an adjusted dose to avoid excessive buildup of the drug in their system. Additionally, some medications or supplements that affect these liver enzymes (like certain antibiotics or grapefruit juice) may interact with Lunesta and change how it works.

This balance of working fast and lasting long enough is part of why Lunesta is such a helpful option for many people.

Is Lunesta a benzodiazepine?

No, Lunesta isn’t classified as a benzodiazepine. It’s classified as a non-benzodiazepine hypnotic and belongs to a group of popular sleep-inducing medications called “Z-drugs”.

Lunesta might sound similar to older sleep drugs like benzodiazepines because both work by enhancing the calming effects of GABA. However, some key differences make Lunesta a better option for many people.

Older drugs, like benzodiazepines, were effective but often came with stronger side effects. Many users reported feeling groggy or drowsy the next day, which could interfere with daily activities. Additionally, these medications had a higher risk of dependence, meaning people could become addicted to them or need higher doses over time to achieve the same effects.

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Lunesta was specifically designed to avoid most of these problems. It has a different chemical structure than benzodiazepines, so it produces fewer daytime side effects, like grogginess, and has a lower potential for addiction. This makes Lunesta a gentler and safer option, particularly for people who need consistent, long-term help with their sleep.

Like any medication, Lunesta comes with potential side effects that range from mild inconveniences to more serious concerns. Knowing what to expect can help you weigh the benefits and risks of the medication and seek help if needed. Below, we will take a closer look at the most common side effects, the worst side effects and potential side effects in elderly people.

What are the most common side effects of Lunesta?

The majority of users tolerate Lunesta well, but some commonly reported side effects ^[3] include:

Daytime drowsiness: Taking Lunesta too late at night or not getting a full 7–8 hours of sleep can result in feeling groggy or sluggish the next day.
Dizziness: Lightheadedness may occur, especially when standing up too quickly, as Lunesta can temporarily affect your balance.
Dry mouth: This side effect is reported by many users and can often be managed by staying hydrated or using oral moisturizing products.
Unpleasant taste (dysgeusia): A metallic or bitter taste in the mouth is a hallmark side effect of Lunesta, with some individuals describing it as a lingering taste that doesn’t go away easily.
Headaches: Mild to moderate headaches are another relatively common complaint, particularly when starting the medication or adjusting the dose.

What are the worst side effects of Lunesta?

While uncommon, Lunesta can sometimes lead to more severe adverse effects ^[3] that require immediate medical attention:

Complex sleep behaviors: Activities such as sleepwalking, sleep-driving, or even cooking and eating while asleep have been reported in rare cases. These behaviors can be dangerous, especially since the individual typically has no memory of the event.
Severe allergic reactions: Symptoms such as rash, difficulty breathing, or swelling of the face, tongue, or throat could signal a serious allergic reaction and warrant immediate medical care.
Mood changes: Depression, anxiety, irritability, and even suicidal thoughts have been reported in a small percentage of users. It’s important to monitor for these changes, especially if there’s a history of mental health issues.
Memory impairment: Some users experience difficulty recalling events that occurred while under the influence of the medication, particularly if they were not fully asleep.

Lunesta side effects in elderly people

Lunesta’s side effects may be more pronounced in older individuals due to slower metabolism and increased sensitivity to sedatives. This population should take extra caution when using the medication. Common issues include:

Increased risk of falls: Dizziness and impaired motor coordination can significantly raise the risk of falls and related injuries, such as fractures.
Cognitive impairment: Older adults may experience confusion, memory problems, or slowed reaction times, which can interfere with daily functioning.
Prolonged sedation: Because the drug’s effects may last longer in elderly individuals, it’s not uncommon for them to feel drowsy or less alert even the next day.

As previously mentioned, the risk of abuse and dependence ^[2]is lower when using Lunesta compared to benzodiazepines. However, it’s still essential to use it responsibly as accidental overdoses or misuse can lead to serious health complications. Understanding the risks can help prevent these outcomes.

Eszopiclone overdose side effects

An overdose of Lunesta, especially if taken in high doses or combined with other substances like alcohol or sedatives, can have severe consequences. Common symptoms include:

Severe sedation: Overwhelming drowsiness or difficulty staying awake, which may lead to impaired judgment and mobility.
Respiratory depression: Breathing can become dangerously slow or shallow, limiting oxygen delivery to the body and brain.
Loss of consciousness or coma: In extreme cases, an overdose can cause a person to lose consciousness or even fall into a coma.

Emergency action: If an overdose is suspected, seek immediate medical attention. Time is critical, as severe respiratory depression or coma can be life-threatening without prompt intervention.

What to do if you accidentally took 2 Lunesta pills

If you have accidentally taken 2 Lunesta pills or more than your prescribed dose, it’s usually nothing to worry about. Studies ^[3]have shown that an overdose of 36 mg of eszopiclone (a lot more than 2 pills) has proven non-fatal, meaning that a few extra pills should not do any harm. However, taking more than your prescribed dose of Lunesta can amplify its side effects and increase the risk of complications. Common reactions include:

Excessive drowsiness: Profound sedation that may make it difficult to stay awake or function normally during the day.
Cognitive impairment: Symptoms such as confusion, difficulty concentrating, or memory lapses.
Respiratory depression: In rare cases, taking an extra dose may cause shallow or slow breathing, especially in individuals with underlying health issues.

What to do:

Do not drive or operate machinery: Even if you feel fine initially, drowsiness and cognitive effects can appear unexpectedly.
Contact a medical professional: Call your doctor or a poison control center for advice on how to proceed.
Monitor symptoms: Watch for any signs of severe drowsiness, difficulty breathing, or unresponsiveness, and call emergency services if these occur.

Does Lunesta get you high?

No, Lunesta is not typically associated with producing a “high” or euphoria when used as prescribed. However, misuse – such as taking higher-than-recommended doses or combining it with alcohol or other depressants – may lead to a sedative “high”. There is some evidence ^[3]that taking eszopiclone at twice the recommended dose, 6 and 12 mg, can result in euphoric effects as well as memory loss and hallucinations.

This misuse has been reported in recreational settings, particularly among individuals seeking the calming or drowsy effects of the drug. However, such misuse is dangerous and significantly increases the risk of overdose, respiratory depression, and other adverse effects.

The potential for Lunesta abuse

Although Lunesta is generally considered safer and less habit-forming than benzodiazepines, it’s not entirely without risk. Misuse and dependence can develop, and it increases with the dose and duration of treatment ^[1], especially if the drug is used inappropriately over a long period.

Signs of Lunesta abuse:

Escalating dosages: taking more than the prescribed amount to achieve the desired effects, such as falling asleep faster or staying asleep longer.
Dependence: relying on Lunesta to sleep every night, to the point where stopping the medication results in withdrawal symptoms such as rebound insomnia, anxiety, or irritability.
Recreational use: taking Lunesta without a prescription or outside medical guidance for its sedative effects.

Long-term risks of abuse:

Chronic misuse of Lunesta can lead to tolerance, meaning the body requires higher doses to achieve the same effect. This increases the likelihood of side effects, overdose, and withdrawal symptoms when stopping the drug.

How to minimize the risks of overdose and abuse:

Follow prescriptions closely: Always stick to the dose and schedule recommended by your doctor.
Avoid mixing with other substances: Do not combine Lunesta with alcohol, sedatives, or recreational drugs, as this significantly increases the risk of dangerous side effects.
Communicate with your doctor: If you feel the medication isn’t working as effectively, speak with your doctor rather than increasing your dose on your own.
Use for short-term relief: Whenever possible, aim to use Lunesta as a short-term solution for insomnia while addressing underlying sleep issues through non-drug therapies like cognitive-behavioral therapy (CBT).

While Lunesta is an effective medication for managing insomnia, it can have various effects on mental health that users should be aware of. While it primarily helps with sleep, some people may experience side effects that impact their mood, anxiety levels, or emotional well-being, particularly with long-term use.

Can Lunesta cause anxiety?

Although Lunesta is intended to help with relaxation and sleep, paradoxically, some individuals may experience increased anxiety as a side effect. Although this isn’t common, it has been reported ^[1] related to withdrawal from the drug or rebound insomnia. Rebound insomnia occurs when the medication’s calming effects wear off, and the underlying sleep problems return even stronger. In such cases, anxiety can be heightened as the person struggles to sleep without the assistance of Lunesta.

Common symptoms of anxiety during withdrawal or rebound insomnia include:

Restlessness: Feeling an inability to relax, often accompanied by pacing or fidgeting.
Agitation: Irritability or a sense of frustration that can make it difficult to calm down or stay composed.
Heightened worry or panic attacks: A sense of overwhelming worry that can escalate into panic attacks, making the situation even more stressful.

These effects can be temporary for most people, but they can be difficult to manage, especially when they interfere with a person’s ability to sleep or function during the day. It’s important to consult a doctor if you notice these symptoms, as they can help guide you through a safer way to taper off Lunesta if necessary.

Is Lunesta addictive?

Compared to older sleep medications like benzodiazepines, Lunesta has a lower potential for addiction. Clinical studies ^[2]have not found sufficient evidence that Lunesta is addictive even if patients stopped taking it after several weeks or months of treatment. However, like any medication that affects the brain’s chemistry, it’s still possible to become dependent on Lunesta, especially with prolonged or inappropriate use. Dependence on Lunesta can manifest in both psychological and physical forms:

Psychological addiction occurs when someone feels they cannot sleep without the help of the drug. Over time, the brain may come to rely on the calming effects of Lunesta to fall asleep, and the person may develop an emotional or mental reliance on the medication. This can lead to feelings of anxiety or frustration when they are unable to use Lunesta, even if they do not need it for sleep.

Physical dependence is another form of addiction where the body adjusts to the presence of the drug. If the medication is stopped abruptly, withdrawal symptoms may occur. These can include:

Irritability: Increased frustration or anger that may seem out of proportion to the situation.
Anxiety: A sense of nervousness or unease that becomes difficult to control.
Insomnia: The very problem the medication was originally meant to address may worsen, making it difficult to sleep naturally.

Though the risk of addiction is lower with Lunesta than with other sedatives, it’s still important to be mindful of the duration and dosage to avoid dependence. If you have concerns about becoming reliant on Lunesta, discuss them with your healthcare provider, who can help adjust your treatment plan or explore alternative options.

Recovering from Lunesta addiction involves addressing both physical dependence and the underlying causes of insomnia. A combination of medical and psychological interventions is typically the most effective approach.

Key steps in treatment include:

Medical detoxification
Gradually tapering off Lunesta under medical supervision helps minimize withdrawal symptoms, such as rebound insomnia or anxiety. Doctors may provide temporary alternatives to manage symptoms or, in severe cases, recommend hospitalization for safety.
Cognitive Behavioral Therapy for Insomnia (CBT-I)
CBT-I is an evidence-based approach that addresses the root causes of sleep problems without medications. It includes strategies like sleep restriction, stimulus control, and cognitive restructuring to improve sleep habits and reduce anxiety about sleep.
Support groups and counseling
Peer support from organizations like SMART Recovery or Narcotics Anonymous can help individuals feel understood and motivated. Individual counseling further addresses emotional triggers or stress that may have contributed to dependence.
Healthy lifestyle adjustments
Adopting better sleep habits, such as maintaining a consistent sleep schedule, creating a relaxing bedtime routine, and avoiding stimulants, can support long-term recovery. Regular exercise and a balanced diet can also enhance overall well-being.

Lunesta has proven to be a valuable tool for managing insomnia, offering many individuals the relief they need to achieve restorative sleep. However, as with any medication, it comes with potential risks, including side effects, dependence, and misuse. By understanding how Lunesta works, its benefits, and its potential challenges, individuals can make more informed decisions in collaboration with healthcare providers. For those struggling with dependence, effective treatments and support systems are available to guide them toward recovery. Proper usage and a holistic approach to sleep health can ensure Lunesta remains a helpful, rather than harmful, solution.

Brielmaier B. D. (2006). Eszopiclone (Lunesta): a new nonbenzodiazepine hypnotic agent. Proceedings (Baylor University. Medical Center), 19(1), 54–59. https://doi.org/10.1080/08998280.2006.11928127 https://pmc.ncbi.nlm.nih.gov/articles/PMC1325284/

2. Rösner, S., Englbrecht, C., Wehrle, R., Hajak, G., & Soyka, M. (2018). Eszopiclone for insomnia. The Cochrane database of systematic reviews, 10(10), CD010703. https://doi.org/10.1002/14651858.CD010703.pub2 https://pmc.ncbi.nlm.nih.gov/articles/PMC6492503/

3. McCrae, C. S., Ross, A., Stripling, A., & Dautovich, N. D. (2007). Eszopiclone for late-life insomnia. Clinical interventions in aging, 2(3), 313–326. https://pmc.ncbi.nlm.nih.gov/articles/PMC2685268/

FAQs

How quickly does Lunesta work?

Lunesta starts working within 30 minutes to 1 hour of ingestion. For optimal results, take it immediately before bedtime when you’re ready to sleep.

Can Lunesta be used long-term?

Lunesta is generally prescribed for short-term use to treat insomnia. Long-term use may increase the risk of dependence or tolerance, so it’s important to consult your doctor about the duration of treatment.

What should I do if I miss a dose?

If you miss a dose of Lunesta, skip it and take your next dose at the usual time. Do not double the dose to make up for the missed one, as it may increase the risk of side effects like excessive drowsiness.

Is it safe to take Lunesta with alcohol?

No, combining Lunesta with alcohol is dangerous. Both substances can amplify sedative effects, increasing the risk of respiratory depression, extreme drowsiness, or even life-threatening complications.

Can Lunesta be stopped abruptly?

Abruptly stopping Lunesta, especially after long-term use, may cause withdrawal symptoms such as rebound insomnia, anxiety, or irritability. Always consult your healthcare provider before discontinuing the medication, as they can create a tapering plan to minimize withdrawal effects.

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